Now available!

If your
migraine
is here,

Why
only send
treatment
here?

Send medication directly  to the back of the nose with a new Breath Powered® delivery system Learn why the nose matters ›

About
Migraines and
Sumatriptan

  • Migraine is a neurological disorder. During an attack, your nerves release inflammatory substances that cause your blood vessels to expand. This causes painful throbbing
  • In addition to pain, some people also have to deal with migraine-related nausea, vomiting, or sensitivity to light and sound
    • Taking something different than pills may be an option to consider for people with nausea or vomiting

When talking to your doctor about ONZETRA® Xsail®, remember to discuss all of your symptoms and medical conditions.

Common treatment for migraines

There are several medicines for migraines. The most widely prescribed medicine is sumatriptan, which has been used safely and effectively for over 20 years.

Unlike most other sumatriptan options, ONZETRA takes a different route

ONZETRA is rapidly absorbed sumatriptan nasal powder delivered to the back of the nose.

ONZETRA Xsail is approved for the acute treatment of migraine, with or without aura in adults. Only your doctor can determine if ONZETRA Xsail is right for you. ONZETRA Xsail is not for the prevention of migraines or for the treatment of other types of headaches.

Why
Onzetra
Xsail?

ONZETRA Xsail is different than anything you’ve used before.

It is not a liquid nasal spray or an inhaler. It’s a Breath Powered® nasal delivery system for the acute treatment of migraines.

ONZETRA is taken with a small, innovative device called Xsail. It uses your own breath to deliver sumatriptan to the back of your nose.

Research suggests that the back of the nose is rich in blood vessels and absorbent tissue, which may help deliver medication into the bloodstream.

Breath Powered® delivery:
How it works is why it works differently

The Xsail device was designed to deliver medication to the back of your nose and it conveniently fits in the palm of your hand.

ONZETRA Xsail is a prescription medication approved for the acute treatment of migraine, with or without aura in adults. ONZETRA Xsail is used for people who have been told by a healthcare provider that they have migraine headaches. ONZETRA Xsail is not for the prevention of migraines or for other types of headaches, including cluster headache.

Blow

Exhaling forcefully propels the sumatriptan powder into the back of your nose

Widen

The specially designed nosepiece helps to gently widen the nasal valve, opening the route to the back of the nose

Deliver

ONZETRA targets an area in the back of your nose with the potential for fast absorption

Close

Blowing into the device closes the flap, separating the back of the nose from the throat, which may help limit the amount of medication reaching the stomach or lungs

Please refer to the complete Instructions for Use found within the full Prescribing Information to ensure proper use.

The back of the nose
may be a good place
to send medicine

Your nose is made of valves and cavities

NASAL VALVE

Your nasal valve is a dynamic area in your nose that’s shaped like a small triangle. It helps you breathe air in while keeping foreign particles out. It has a good purpose, but may limit how well medication is delivered through your nose.

The ONZETRA® Xsail® nosepiece widens the nasal valve, helping medication reach the back of your nose.

POSTERIOR NASAL CAVITY

Your nose is divided into two cavities. The anterior cavity at the front helps protect your lungs from particles that enter your nose. The posterior nasal cavity in the back of your nose may help absorb things, like medication.

It is rich in blood vessels and absorbent tissue, which may help deliver medication into the bloodstream.

To learn how to use ONZETRA Xsail, please refer to the Instructions for Use.

X

NEARLY 90% of people found ONZETRA XSAIL easy to use

If relief
can be
quick

Will it
also
stick?

ONZETRA provides FAST relief that may LAST with one dose

30 minutes

Almost half of migraine sufferers experienced pain relief in 30 minutes (42% vs 27% on placebo) and 68% experienced pain relief in 2 hours vs 45% on placebo

2 hours

Twice as many people were pain free at 2 hours versus people not taking ONZETRA (34% vs 17% on placebo)

48 hours

Within 48 hours of the initial dose, 63% of people who used ONZETRA did not take another dose or additional medication (vs 48% on placebo)*

*Patients were not asked why they did not take another dose or additional medication.

ONZETRA Xsail may cause serious side effects and should not be used by certain patients, including those with a history of heart problems or who have had a stroke. These are not all the risks of use for ONZETRA Xsail.

Safety and tolerability of ONZETRA Xsail

What are the side effects?

In the clinical studies, sensations typically associated with triptans (i.e., chest pressure and tightness) were reported in less than 2% of attacks treated with ONZETRA. None of these events were serious or led people to discontinue ONZETRA. These sensations commonly occur after treatment with triptans and are usually non-cardiac in origin. However, if you have heart problems or a history of heart problems be sure to tell your doctor before using ONZETRA.

The most common side effects reported by people using ONZETRA were:

  • A mild metallic taste
  • Nasal discomfort
  • Runny nose and stuffy nose

These are not all the possible risks of ONZETRA. Tell your doctor about any side effect that bothers you or does not go away. For additional Important Safety Information about ONZETRA Xsail, please see the full Prescribing Information, including Patient Information and Instructions for Use.

Now that you’ve been introduced to ONZETRA, what would you like to do next?

Important Safety Information

ONZETRA Xsail may cause serious side effects, including heart attack and other heart problems, which may lead to death. Stop using ONZETRA Xsail and get emergency medical help right away if you have any symptoms of a heart attack like shortness of breath or tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw that is severe or does not go away. Click here for more information

Important Safety Information

What is ONZETRA® Xsail® (sumatriptan nasal powder) used for?
ONZETRA Xsail is a prescription medication approved for the acute treatment of migraine, with or without aura in adults. ONZETRA Xsail is used for people who have been told by a healthcare provider that they have migraine headaches. ONZETRA Xsail is not for the prevention of migraines or for other types of headaches, including cluster headache.

What important information should I know about ONZETRA Xsail?
ONZETRA Xsail may cause serious side effects, including:

  • Heart attack and other heart problems, which may lead to death. Stop using ONZETRA Xsail and get emergency medical help right away if you have any symptoms of a heart attack like shortness of breath or tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw that is severe or does not go away
  • Changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • Stomach and intestinal problems (gastrointestinal and colonic ischemic events)
  • Problems with blood circulation to your legs and feet (peripheral vascular ischemia)
  • Serious allergic reactions (symptoms include hives; tongue, mouth, lip, or throat swelling; problems breathing)
  • Medication overuse headaches. Some people who use ONZETRA Xsail too many times may have worse headaches. If your headaches get worse your doctor may decide to stop your treatment with ONZETRA Xsail
  • Serotonin syndrome, a rare but serious problem that can happen in people using ONZETRA Xsail, especially if ONZETRA Xsail is used with antidepressant medicines called SSRIs, SNRIs, or TCAs. Call your doctor right away if you have any of the following symptoms of serotonin syndrome: mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; trouble walking; or nausea, vomiting, or diarrhea
  • Seizures. Seizures have happened in people taking sumatriptan who have never had seizures before

The most common side effects of ONZETRA Xsail are abnormal taste, discomfort of your nose or throat, runny nose, and stuffy nose. This is not a complete list of side effects. Tell your doctor about any side effect that bothers you or does not go away.

Who should not take ONZETRA Xsail?
Do not take ONZETRA Xsail or stop using ONZETRA Xsail if you:

  • Have heart problems or a history of heart problems
  • Have had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation
  • Have uncontrolled high blood pressure
  • Have hemiplegic migraines or basilar migraines. If you are not sure if you have these, ask your doctor
  • Have peripheral vascular disease (narrowing of blood vessels to the legs, arms, stomach, intestines, or kidneys)
  • Have taken other migraine medications in the last 24 hours, including other triptans, ergots, or ergot-type medications. Ask your doctor for a list of these medicines if you are not sure
  • Are taking a medicine called a monoamine oxidase inhibitor (MAOI). MAOIs cannot be taken within 14 days before or after taking ONZETRA Xsail
  • Have severe liver problems
  • Have an allergy to sumatriptan, the medicine in ONZETRA Xsail, or any of the components in ONZETRA Xsail

What should I tell my healthcare provider before taking ONZETRA Xsail?
Before you take ONZETRA Xsail, tell your doctor about all your medical conditions and all the medicines you take, including prescription medicines, especially antidepressants, and all over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while taking ONZETRA Xsail?
ONZETRA Xsail can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 800-FDA-1088.

For additional Important Safety Information about ONZETRA Xsail, please see the full Prescribing Information, including Patient Information and Instructions for Use.