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How ONZETRA Works

The Science Behind ONZETRA Xsail

The unique Breath Powered® mechanism provides direct and efficient delivery of a low dose of sumatriptan nasal powder into the posterior nasal cavity, limiting medication diversion to the GI tract.
Woman with blue shirt relived of acute migraine
Nearly 90% of patients studied found ONZETRA easy to use*

*Out of 108 questionnaire participants, 90 patients found the device somewhat easy or very easy to use.

Steps to Fast, Sustained Relief

Steps to Fast, Sustained Relief

How to use ONZETRA® Xsail® (sumatriptan nasal powder) device
1. Prepare the Medication

Insert 1 nosepiece into the device. Fully press and release the white button to pierce the capsule. If you skip this step, you will not get any medication.

Woman using application device ONZETRA® Xsail® (sumatriptan nasal powder)
2. Position the Device
Insert the nosepiece deeply into your nose and rotate the device to place the mouthpiece into your mouth.
Woman breathing into application device ONZETRA® Xsail® (sumatriptan nasal powder)
3. Blow Steadily
Blow into the device for 2 to 3 seconds. Take the nosepiece out of the device and throw it away.
Repeat steps 1 to 3 with the second nosepiece in the other nostril
These are not the complete Instructions for Use. Please refer to the complete Instructions for Use found within the Patient Information to ensure proper use.

Talk to a doctor to find out if ONZETRA Xsail is right for you

Woman having a telemedicine consultation about migraine

Be sure to tell your doctor if you

  • Are experiencing migraines
  • Are not fully satisfied with your current treatment
  • Experience nausea or vomiting during a migraines
  • Want a treatment that is well tolerated
  • Want something different that also offers fast relief
  • Need an option with relief that can last

Talk to a doctor to find out if ONZETRA Xsail is right for you

Be sure to tell your doctor if you

  • Are experiencing migraines
  • Are not fully satisfied with your current treatment
  • Experience nausea or vomiting during a migrane
  • Want a treatment that is well tolerated
  • Want something different that also offers fast relief
  • Need an option with relief that can last
Or if you’re ready, talk to a doctor online today
Talk to a Doctor Online about ONZETRA
For more information about ONZETRA, see our Resources Page.
Or if you’re ready, talk to a doctor online today
Talk to a Doctor Online about ONZETRA
Talk to a Doctor Online about ONZETRA

For more information about ONZETRA, see our Resources Page.

Onzetra Xsail application device for fast relief
ONZETRA® Offers the Opportunity for Efficient Intranasal Drug Delivery
It is the first and only Breath Powered®
intranasal delivery system
Woman wearing a pink fedora smiling walking a dog
Onzetra Xsail application device for fast relief
ONZETRA® Offers the Opportunity for Efficient Intranasal Drug Delivery

It is the first and only Breath Powered® intranasal delivery system

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ONZETRA Xsail isn’t the typical delivery system — a pill, a nasal spray, or an injection

It’s a prescription inhaler that sends migraine pain on its way

Learn About ONZETRA
Learn About ONZETRA
IMPORTANT SAFETY INFORMATION
What is ONZETRA® Xsail®
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IMPORTANT SAFETY INFORMATION
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ONZETRA Xsail may cause serious side effects, including:

  • Heart attack and other heart problems, which may lead to death. Stop using ONZETRA Xsail and get emergency medical help right away if you have any symptoms of a heart attack like shortness of breath or tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw that is severe or does not go away
  • Changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • Stomach and intestinal problems (gastrointestinal and colonic ischemic events)
  • Problems with blood circulation to your legs and feet (peripheral vascular ischemia)
  • Serious allergic reactions (symptoms include hives; tongue, mouth, lip, or throat swelling; problems breathing)
  • Medication overuse headaches. Some people who use ONZETRA Xsail too many times may have worse headaches. If your headaches get worse your doctor may decide to stop your treatment with ONZETRA Xsail
  • Serotonin syndrome, a rare but serious problem that can happen in people using ONZETRA Xsail, especially if ONZETRA Xsail is used with antidepressant medicines called SSRIs, SNRIs, or TCAs. Call your doctor right away if you have any of the following symptoms of serotonin syndrome: mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; trouble walking; or nausea, vomiting, or diarrhea
  • Seizures. Seizures have happened in people taking sumatriptan who have never had seizures before

The most common side effects of ONZETRA Xsail are abnormal taste, discomfort of your nose or throat, runny nose, and stuffy nose. This is not a complete list of side effects. Tell your doctor about any side effect that bothers you or does not go away.

Who should not take ONZETRA Xsail?

Do not take ONZETRA Xsail or stop using ONZETRA Xsail if you:

  • Have heart problems or a history of heart problems
  • Have had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation
  • Have uncontrolled high blood pressure
  • Have hemiplegic migraines or basilar migraines. If you are not sure if you have these, ask your doctor
  • Have peripheral vascular disease (narrowing of blood vessels to the legs, arms, stomach, intestines, or kidneys)
  • Have taken other migraine medications in the last 24 hours, including other triptans, ergots, or ergot-type medications. Ask your doctor for a list of these medicines if you are not sure
  • Are taking a medicine called a monoamine oxidase inhibitor (MAOI). MAOIs cannot be taken within 14 days before or after taking ONZETRA Xsail
  • Have severe liver problems
  • Have an allergy to sumatriptan, the medicine in ONZETRA Xsail, or any of the components in ONZETRA Xsail

What should I tell my healthcare provider before taking ONZETRA Xsail?

Before you take ONZETRA Xsail, tell your doctor about all your medical conditions and all the medicines you take, including prescription medicines, especially antidepressants, and all over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while taking ONZETRA Xsail?

ONZETRA Xsail can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see the full Prescribing Information, including Patient Information and Instructions for Use for ONZETRA Xsail.
What is ONZETRA® Xsail®
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What is ONZETRA® Xsail®
ONZETRA® Xsail® is a prescription medication approved for the acute treatment of migraine, with or without aura in adults. ONZETRA Xsail is used for people who have been told by a healthcare provider that they have migraine headaches. ONZETRA Xsail is not for the prevention of migraines or for other types of headaches, including cluster headache.

© 2022 Currax Pharmaceuticals LLC.
ONZ-0035-001 06/22

All rights reserved. ONZETRA and Xsail are registered trademarks of Currax Pharmaceuticals LLC. Breath Powered is a registered trademark of OptiNose AS.

© 2022 Currax Pharmaceuticals LLC. All rights reserved. ONZETRA and Xsail are registered trademarks of Currax Pharmaceuticals LLC. Breath Powered is a registered trademark of OptiNose AS.
ONZ-0035-001 06/22

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