Rapid relief is possible with Breath Powered® ONZETRA Xsail

*42% of patients achieved significant pain relief vs 27% on placebo.

At 24 hours, 28% of patients maintained pain freedom vs 12% in the placebo group, and 20% vs 9% were pain-free at 48 hours.

Clinical Trial Information for ONZETRA

TARGET Clinical Trial

Who Participated

230 adults, diagnosed at least 1 year prior to screening with episodic migraine with or without aura, who were randomly assigned to either receive ONZETRA or a placebo.

Study Objectives

  • Studied the efficacy and safety of ONZETRA 22 mg vs placebo
  • Measured the percentage of patients with headache relief at 2 hours
  • Measured the percentage of patients with pain relief and pain freedom at time intervals up to 120 minutes, meaningful relief, rescue medication use, and sustained pain relief at 24 and 48 hours


  • At 30 minutes, 42% of patients achieved significant paint relief vs 27% on placebo
  • At 2 hours, 68% of patients achieved significant pain relief vs 45% on placebo
  • At 48 hours, 34% of patients achieved significant pain relief vs 20% on placebo

The Safety of ONZETRA Xsail

Learn about the common side effects and risks for ONZETRA

  • A mild metallic taste (no patient stopped taking ONZETRA due to abnormal taste)
  • Nasal discomfort
  • Runny or stuffy nose
  • Triptan sensations, which affected 2% or fewer people taking ONZETRA Xsail
Triptan sensations are usually not caused by a heart condition. They include: paraesthesias (tingling or numbness of the skin), flushing, neck pain, and mild transient chest pressure. None of these events were serious or led people to discontinue ONZETRA. However, if you have heart problems or a history of heart problems, be sure to tell your doctor before using ONZETRA. ONZETRA may cause serious side effects and should not be used by certain patients, including those with a history of heart problems or who have had a stroke. These are not all the risks of use for ONZETRA. Tell your doctor about any side effect that bothers you or does not go away. Please see additional Important Safety Information about ONZETRA Xsail below, and the full Prescribing Information, including Patient Information and Instructions for Use.

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